Dr Edwige Roy
Honorary Research Fellow & Senior Research Coordinator
Frazer Institute
+61 7 334 66078
Book Chapter
Roy, Edwige and Khosrotehrani, Kiarash (2018). Whole-mount immunofluorescent staining coupled to multicolor lineage tracing model for analyzing the spatiotemporal organization of epidermal stem cells. Skin stem cells: methods protocols. (pp. 111-118) edited by Kursad Turksen. New York, NY, United States: Humana Press. doi: 10.1007/7651_2018_165
Journal Articles
Sormani, L., Hashemi, G., Li, H., Zhou, C., Li, K., Chan, S., Tan, S.X., Nguyen, Q., Roy, E. and Khosrotehrani, K. (2024). 381 Endothelial progenitors: Unlocking Tumor Vessel Normalization to Overcome Therapeutic Challenges in Melanoma. Journal of Investigative Dermatology, 144 (12), S294. doi: 10.1016/j.jid.2024.10.391
Muller, N.M., Tan, S.X., Galbraith, J., Zhou, C., Roy, E. and Khosrotehrani, K. (2024). 533 Systems genetics multi-trait analysis of mouse wound healing reveals novel trait interactions with candidate genes characterised by their epidermal expression niche. Journal of Investigative Dermatology, 144 (12), S320. doi: 10.1016/j.jid.2024.10.546
Dousset, Lea, Chambers, Daniel C., Webster, Angela, Isbel, Nicole, Campbell, Scott, Duarte, Carla, Collins, Louisa, Damian, Diona, Tseng, Anne, Karlsen, Emma, Ilinsky, Olga Victoria, Brown, Susan, Schaider, Helmut, Soyer, H. Peter, Ospino, Daniel Ariza, Hogarth, Sam, Chong, Alvin H., Mar, Victoria, McKenzie, Scott, Gin, Douglas, Fernandez-Penas, Pablo, Kern, Johannes S., Loewe, Katja, Roy, Edwige, Herschtal, Alan and Khosrotehrani, Kiarash (2024). Trial protocol for SiroSkin: a randomised double-blind placebo-controlled trial of topical sirolimus in chemoprevention of facial squamous cell carcinomas in solid organ transplant recipients. Trials, 25 (1) 789. doi: 10.1186/s13063-024-08619-3
Zhao, Jilai, Sormani, Laura, Jacquelin, Sebastien, Li, Haiming, Styke, Cassandra, Zhou, Chenhao, Beesley, Jonathan, Oon, Linus, Kaur, Simranpreet, Sim, Seen-Ling, Wong, Ho Yi, Dight, James, Hashemi, Ghazaleh, Shafiee, Abbas, Roy, Edwige, Patel, Jatin and Khosrotehrani, Kiarash (2024). Distinct roles of SOX9 in self-renewal of progenitors and mesenchymal transition of the endothelium. Angiogenesis, 27 (3), 1-16. doi: 10.1007/s10456-024-09927-7
Wong, Ho Yi, Lee, Ruby C., Chong, Sharene, Kapadia, Stuti, Freeman, Michael, Murigneux, Valentine, Brown, Susan, Soyer, H. Peter, Roy, Edwige and Khosrotehrani, Kiarash (2023). Epidermal mutation accumulation in photodamaged skin is associated with skin cancer burden and can be targeted through ablative therapy. Science Advances, 9 (19) eadf2384, 1-13. doi: 10.1126/sciadv.adf2384
Chong, Sharene, Wong, Ho Yi, Althabteh, Ahmad, Cox, Charlotte, Stevenson, Paul H., Brown, Susan, Griffin, Anthony, Isbel, Nicole, Siller, Gregory, Soyer, H. Peter, Schaider, Helmut, Roy, Edwige, Campbell, Scott, Green, Adele C. and Khosrotehrani, Kiarash (2022). Chemoprevention of cutaneous squamous cell carcinoma and its precursors in solid organ transplant recipients using topical sirolimus: a randomized, double-blind, placebo-controlled pilot trial. Journal of the American Academy of Dermatology, 87 (5), 1163-1166. doi: 10.1016/j.jaad.2022.02.039
Villani, Rehan, Murigneux, Valentine, Alexis, Josue, Sim, Seen-Ling, Wagels, Michael, Saunders, Nicholas, Soyer, H. Peter, Parmentier, Laurent, Nikolaev, Sergey, Fink, J. Lynn, Roy, Edwige and Khosrotehrani, Kiarash (2021). Subtype specific analyses reveal infiltrative basal cell carcinoma are highly interactive with their environment. The Journal of Investigative Dermatology, 141 (10), 2380-2390. doi: 10.1016/j.jid.2021.02.760
Zhao, Jilai, Patel, Jatin, Kaur, Simranpreet, Sim, Seen-Ling, Wong, Ho Yi, Styke, Cassandra, Hogan, Isabella, Kahler, Sam, Hamilton, Hamish, Wadlow, Racheal, Dight, James, Hashemi, Ghazaleh, Sormani, Laura, Roy, Edwige, Yoder, Mervin C., Francois, Mathias and Khosrotehrani, Kiarash (2021). Sox9 and Rbpj differentially regulate endothelial to mesenchymal transition and wound scarring in murine endovascular progenitors. Nature Communications, 12 (1) 2564, 1-17. doi: 10.1038/s41467-021-22717-9
Wong, Ho Yi, Khosrotehrani, Kiarash and Roy, Edwige (2021). Whole-mount staining coupled to a UV-inducible basal cell carcinoma murine model. STAR protocols, 2 (1) 100329, 100329. doi: 10.1016/j.xpro.2021.100329
Roy, Edwige, Wong, Ho Yi, Villani, Rehan, Rouille, Thomas, Salik, Basit, Sim, Seen Ling, Murigneux, Valentine, Stark, Mitchell S., Fink, J. Lynn, Soyer, H. Peter, Walker, Graeme, Lyons, J. Guy, Saunders, Nicholas and Khosrotehrani, Kiarash (2020). Regional Variation in Epidermal Susceptibility to UV-Induced Carcinogenesis Reflects Proliferative Activity of Epidermal Progenitors. Cell Reports, 31 (9) 107702, 107702. doi: 10.1016/j.celrep.2020.107702
Villani, Rehan, Sim, Seen Ling, Roy, Edwige, Wainwright, Brandon, Francois, Mathias and Khosrotehrani, Kiarash (2020). Ectopic expression of SOX18 in Basal cell carcinoma negatively regulates tumour progression. Journal of Dermatological Science, 98 (3), 179-185. doi: 10.1016/j.jdermsci.2020.04.006
Sim, Seen-Ling, Alexis, Josue, Roy, Edwige, Shafiee, Abbas, Khosrotehrani, Kiarash and Patel, Jatin (2018). Immunosuppression agent cyclosporine reduces self-renewal and vessel regeneration potentiation of human endothelial colony forming cells: deleterious effect of cyclosporine on ECFC. STEM CELLS Translational Medicine, 8 (2), 162-168. doi: 10.1002/sctm.18-0103
Legrand, Julien M. D., Roy, Edwige, Baz, Batoul, Mukhopadhyay, Pamela, Wong, Ho Yi, Ram, Ramesh, Morahan, Grant, Walker, Graeme and Khosrotehrani, Kiarash (2018). Genetic variation in the MAPK/ERK pathway affects contact hypersensitivity responses. Journal of Allergy and Clinical Immunology, 142 (3), 981-984.e7. doi: 10.1016/j.jaci.2018.04.028
Roy, Edwige and Khosrotehrani, Kiarash (2018). Past stem cells and finally in transit: SLC1A3 instructs skin niche coupling. The EMBO Journal, 37 (9) e99393, e99393. doi: 10.15252/embj.201899393
Castela, Mathieu, Linay, Fabien, Roy, Edwige, Moguelet, Philippe, Xu, Jie, Holzenberger, Martin, Khosrotehrani, Kiarash and Aractingi, Selim (2017). Igf1r signalling acts on the anagen-to-catagen transition in the hair cycle. Experimental Dermatology, 26 (9), 785-791. doi: 10.1111/exd.13287
Khosrotehrani, Kiarash and Roy, Edwige (2017). Tell me about your stemness. I’ll give your cancer risk!. Cell Death and Differentiation, 24 (1), 6-7. doi: 10.1038/cdd.2016.144
Roy, Edwige, Neufeld, Zoltan, Cerone, Luca, Wong, Ho Yi, Hodgson, Samantha, Livet, Jean and Khosrotehrani, Kiarash (2016). Bimodal behaviour of interfollicular epidermal progenitors regulated by hair follicle position and cycling. EMBO Journal, 35 (24), 2658-2670. doi: 10.15252/embj.201693806
Legrand, Julien M. D., Roy, Edwidge, Ellis, Jonathan J., Francois, Mathias, Brooks, Andrew J. and Khosrotehrani, Kiarash (2016). STAT5 activation in the dermal papilla is important for hair follicle growth phase induction. Journal of Investigative Dermatology, 136 (9), 1781-1791. doi: 10.1016/j.jid.2016.04.014
Roy, Edwige, Neufeld, Zoltan, Livet, Jean and Khosrotehrani, Kiarash (2014). Concise review: understanding clonal dynamics in homeostasis and injury through multicolor lineage tracing. Stem Cells, 32 (12), 3046-3054. doi: 10.1002/stem.1804
Hodgson, Samantha S., Neufeld, Zoltan, Villani, Rehan M., Roy, Edwige and Khosrotehrani, Kiarash (2014). Transgenic flash mice for in vivo quantitative monitoring of canonical wnt signaling to track hair follicle cycle dynamics. Journal of Investigative Dermatology, 134 (6), 1519-1526. doi: 10.1038/jid.2014.92
Roy, Edwige, Seppanen, Elke, Ellis, Rebecca, Lee, Eddy S., Khosroterani, Kiarash, Fisk, Nicholas M. and Bou-Gharios, George (2014). Biphasic recruitment of microchimeric fetal mesenchymal cells in fibrosis following acute kidney injury. Kidney International, 85 (3), 600-610. doi: 10.1038/ki.2013.459
Seppanen, Elke, Roy, Edwige, Ellis, Rebecca, Bou-Gharios, George, Fisk, Nicholas M. and Khosrotehrani, Kiarash (2013). Distant mesenchymal progenitors contribute to skin wound healing and produce collagen: evidence from a murine fetal microchimerism model. PloS One, 8 (5) e62662, e62662. doi: 10.1371/journal.pone.0062662
Roy, Edwige, Leduc, Michele, Guegan, Sarah, Rachdi, Latif, Kluger, Nicolas, Scharfmann, Raphael, Aractingi, Selim and Khosrotehrani, Kiarash (2011). Specific maternal microchimeric T cells targeting fetal antigens in β cells predispose to auto-immune diabetes in the child. Journal of Autoimmunity, 36 (3-4), 253-262. doi: 10.1016/j.jaut.2011.02.003
Roy, Edwige, Togbe, Dieudonnée, Holdorf, Amy, Trubetskoy, Dmitry, Nabti, Sabrina, Küblbeck, Günter, Schmitt, Sabine, Kopp-Schneider, Annette, Leithäuser, Frank, Möller, Peter, Bladt, Friedhelm, Hämmerling, Günter J., Arnold, Bernd, Pawson, Tony and Tafuri, Anna (2010). Fine tuning of the threshold of T cell selection by the Nck adapters. Journal of Immunology, 185 (12), 7518-7526. doi: 10.4049/jimmunol.1000008
Leduc, Michele, Guegan, Sarah, Roy, Edwige, Oster, Michele, Aractingi, Selim and Khosrotehrani, Kiarash (2010). Limited functional capacity of microchimeric fetal hematopoietic progenitors acquired by mothers during pregnancy. Experimental Hematology, 38 (10), 852-853. doi: 10.1016/j.exphem.2010.06.009
Roy, Edwige, Togbe, Dieudonnee, Holdorf, Amy D., Trubetskoy, Dmitry, Nabti, Sabrina, Kublbeck, Gunter, Klevenz, Alexandra, Kopp-Schneider, Annette, Leithauser, Frank, Moller, Peter, Bladt, Friedhelm, Hammerling, Gunter, Arnold, Bernd, Pawson, Tony and Tafuri, Anna (2010). Nck adaptors are positive regulators of the size and sensitivity of the T-cell repertoire. Proceedings of the National Academy of Sciences of USA, 107 (35), 15529-15534. doi: 10.1073/pnas.1009743107
Prevot, Nicolas, Briet, Claire, Lassmann, Hans, Tardivel, Isabelle, Roy, Edwige, Morin, Joelle, Mak, Tak W., Tafuri, Anna and Boitard, Christian (2010). Abrogation of ICOS/ICOS ligand costimulation in NOD mice results in autoimmune deviation toward the neuromuscular system. European Journal of Immunology, 40 (8), 2267-2276. doi: 10.1002/eji.201040416
Conference Papers
Lee, Ruby, Wong, Ho Yi, Brown, Susan, Roy, Edwige, Soyer, Peter and Khosrotehrani, Kiarash (2023). Epidermal somatic mutation is correlated with keratinocyte cancer burden. HOBOKEN: WILEY.
Hashemi, G., Le Bourhis, L. Sormani, Dight, J., Zhou, C., Roy, E. and Khosrotehrani, K. (2023). Targeting tumour vascularisation through endothelial-specific Sox9 deletion reduces melanoma metastasis. 1st International Societies for Investigative Dermatology Meeting (ISID 2023), Tokyo, Japan, 10-13 May 2023. Philadelphia, PA United States: Elsevier. doi: 10.1016/j.jid.2023.03.1288
Wong, H., Lee, R., Chong, S., Kapadia, S., Murigneux, V., Freeman, M., Soyer, H., Roy, E. and Khosrotehrani, K. (2023). Epidermal mutation accumulation in photodamaged skin is associated with skin cancer burden and can be targeted through ablative therapy. 1st International Societies for Investigative Dermatology Meeting, Tokyo, Japan, 12 - 13 May 2023. Oxford, United Kingdom: Elsevier.
Hashemi, G., Sormani Le Bourhis, L., Dight, J., Zhou, C., Roy, E. and Khosrotehrani, K. (2023). Targeting tumour vascularisation through endothelial-specific Sox9 deletion reduces melanoma metastasis. 1st International Societies for Investigative Dermatology Meeting, Tokyo, Japan, May 12-13 2023. Oxford, United Kingdom: Elsevier.
Wong, H., Lee, R., Roy, E., Kapadia, S., Murigneux, V., Chong, S., Freeman, M. and Khosrotehrani, K. (2022). Epidermal ablation reduces keratinocyte cancer burden by lowering skin mutation load. 51st Annual ESDR Meeting, Amsterdam, Netherlands, 28 September-1 October 2022. Oxford, United Kingdom: Elsevier. doi: 10.1016/j.jid.2022.09.449
Lee, R., Wong, H., Brown, S., Roy, E. and Khosrotehrani, K. (2022). Variation in epidermal mutation burden after field treatment with topical 5-fluorouracil. 51st Annual ESDR Meeting, Amsterdam, Netherlands, 28 September-1 October 2022. Oxford, United Kingdom: Elsevier. doi: 10.1016/j.jid.2022.09.504
Roy, E., Wong, H. and Khosrotehrani, K. (2019). Epidermal clonal expansion upon UV irradiation: consequences of the epidermal duality of proliferative behaviour on the skin carcinogenesis. 49th Annual Meeting of the European-Society-for-Dermatological-Research (ESDR), Bordeaux, France, 18-21 September, 2019. Oxford, United Kingdom: Elsevier. doi: 10.1016/j.jid.2019.07.570
Villani, R., Roy, E., Murigneux, V., Sim, S., Malapitan, C., Galbraith, J., Kapadia, S., Fink, L. and Khosrotehrani, K. (2019). Cancer associated fibroblast profiling reveals endothelin signalling as a novel mediator of niche to tumour cross-talk in Basal Cell Carcinoma. 49th Annual Meeting of the European Society for Dermatological Research (ESDR), Bordeaux, France, 18-21 September 2019. New York, NY United States: Elsevier. doi: 10.1016/j.jid.2019.07.507
Wong, H., Roy, E., Kapadia, S., Murigneux, V., Chong, S. and Khosrotehrani, K. (2019). Laser dermabrasion: a potential treatment for non-melanoma skin cancers. 49th Annual Meeting of the European Society for Dermatological Research (ESDR), Bordeaux, France, 18-21 September, 2019. Oxford, United Kingdom: Elsevier. doi: 10.1016/j.jid.2019.07.567
Edwige, Roy, Zoltan, Neufeld, Luca, Cerone, Yi, Wong Ho, Samantha, Hodgson, Jean, Livet and Kiarash, Khosrotehrani (2018). Bimodal behaviour of interfollicular epidermal progenitors regulated by hair follicle position and cycling. Joint 10th Annual Scientific Meeting of the Australian Gene and Cell Therapy Society (AGCTS) and Australasian Society for Stem Cell Research (ASSCR), Sydney, Australia, 24-26 May 2017. Hoboken, NJ United States: John Wiley & Sons. doi: 10.1002/jgm.3003
Roy, E., Legrand, J., Baz, B., Wong, H., Morahan, G., Walker, G. and Khosrotehrani, K. (2018). Genome wide mapping identifies regulation of MAPKinase pathway as key genetic determinant of allergic contact dermatitis. International Investigative Dermatology (IID) Meeting, Orlando, FL, United States, 16 - 19 May 2018. London, United Kingdom: Nature Publishing Group.
Roy, E., Wong, H., Murigneux, V., Fink, L. and Khosrotehrani, K. (2017). Regional variation in epidermal susceptibility to ultraviolet induced carcinogenesis reflects proliferative activity of epidermal progenitors. 47th Annual Meeting of the European-Society-for-Dermatological-Research (ESDR), Salzburg Austria, 27-30 September 2017. London, United Kingdom: Nature Publishing Group. doi: 10.1016/j.jid.2017.07.721
Roy, E., Neufeld, Z., Cerone, L., Wong, H. Y., Hodgson, S., Livet, J. and Khosrotehrani, K. (2016). Dual proliferation behaviour of epidermal progenitors. Asia-Pacific Combined Dermatology Research Conference 2016, Noosa, QLD Australia, 25–28 August 2016. Richmond, VIC Australia: Wiley-Blackwell Publishing Asia. doi: 10.1111/ajd.12584
Roy, E., Wong, H. Y. and Khosrotehrani, K. (2016). Epidermal clonal proliferative response upon UVB irradiation is bimodal. Asia-Pacific Combined Dermatology Research Conference 2016, Noosa, QLD Australia, 25–28 August 2016. Richmond, VIC Australia: Wiley-Blackwell Publishing Asia. doi: 10.1111/ajd.12584
Roy, E., Neufeld, Z., Cerone, L., Wong, A., Hodgson, S., Tabansky, I., Eggan, K., Livet, J. and Khosrotehrani, K. (2013). The interfollicular epidermis is maintained by a hierarchy defined by stem cells within the non-cycling portion of hair follicles and committed progenitors. International Investigative Dermatology Meeting, Edinburgh, Scotland, 8-11 May 2013. London, United Kingdom: Nature Publishing Group. doi: 10.1038/jid.2013.106
Seppanen, E. J., Roy, E., Ellis, R., Gharios, G. Bou, Fisk, N. M. and Khosrtotehrani, K. (2012). Persistent Fetal Progenitors Selectively Home to Maternal Skin Wounds and Express Collagen Type I. HOBOKEN: WILEY-BLACKWELL.
Roy, E., Neufeld, Z., Livet, J. and Khosrotehrani, K. (2012). A multicolour unbiased model to determine the Epidermal cell fate: localization and study of the epidermal stem cell niche. 42nd Annual Meeting of the European Society for Dermatological Research (ESDR), Venice, Italy, 7-10 September 2012. Oxford, United Kingdom: Elsevier. doi: 10.1038/jid.2012.301
Edwige, R., Linay, F, Holzenberger, M., Oster, M., Aractingi, S. and Khosrotehrani, K. (2011). Epidermal IGF-1 receptor is important in the maintenance of bulge stem cell and their response to skin wounds. Annual Meeting of the Society for Investigative Dermatology, Phoenix, Arizona, United States, 4 – 7 May 2011.
Roy, E, Linay, F, Holzenberger, M, Oster, M, Aractingi, S and Khosrotehrani, K (2011). Epidermal IGF-1 receptor is important in the maintenance of bulge stem cells, hair follicle cycle and response to skin wounds. 41st Annual Meeting of the European-Society-for-Dermatological-Research, Barcelona Spain, Sep 07-10, 2011.
Nassar, D., Roy, E., Letavernier, E., Aractingi, S. and Khosrotehrani, K. (2010). CALPAIN INHIBITION AFFECTS GRANULATION TISSUE FORMATION AND RESULTS IN DELAYED WOUND HEALING. 2nd Australasian Wound and Tissue Repair Society (AWTRS) Meeting, Perth, Australia, 22-24 March 2010.