Dr Annette Pflugfelder
PhD Student
Dermatology Research Centre
Email:
Phone:
+617 344 37399
Annette is a medical doctor with a focus on Dermatooncology. Since 2006 she has worked as a resident and scientific co-worker at the Division of Dermato-Oncology, Department of Dermatology in Tübingen, Germany (Head: Prof. Claus Garbe), where she performed her board examination in Dermatology in 2013.
Annette has been involved as a sub-investigator in the care of metastatic melanoma patients. This has included numerous international clinical trials of agents like the subsequently approved anti-CTLA4 antibodies.
Starting in 2009 she has worked as a member of the coordinating group on the development of the first evidence based German Melanoma Guideline, which was published in 2013. She is also involved in the revision of the Clinical Practice Guidelines for the Management of Melanoma by the Cancer Council Australia.
In 2013 she commenced a Joint PhD with the title “Genotypes and phenotypes in metastatic melanoma patients”, at the Eberhard Karls University Tübingen, Germany and The University of Queensland under the supervision of Prof. Garbe, A/Prof. Sturm, A/Prof. Duffy and Prof. Soyer.
In 2013/14 Annette worked for two years in Brisbane at the Institute of Molecular Bioscience and at the Translational Research Institute on the establishment of a large cohort study of melanoma patients and healthy controls to investigate the influence of genetic variants and phenotypes on the development and prognosis of melanoma.
Annette is currently based in Germany at the Eberhard Karls University Tübingen. Her practical and research focus continues to be the improvement of patient care with a special interest in melanoma patients.
Conference Paper
Ling, X., Yong, H., Pflugfelder, A., Duffy, D., Jagirdar, K., Lee, K., Garbe, C., Soyer, H. P. and Sturm, R. (2016). A case-control study of the associations of PGC1 beta genotype with melanoma, skin reflectance, and naevus count. HOBOKEN: WILEY-BLACKWELL.
Gebhardt, Christoffer, Wagner, Nikolaus B., Weide, Benjamin, Lichtenberger, Ramtin, Reith, Maike, Tarnanidis, Kathrin, Ridinger, Johannes, Ikenberg, Kristian, Pflugfelder, Annette, Busch, Christian, Holland-Letz, Tim, Naeher, Helmut, Garbe, Claus, Umansky, Viktor, Enk, Alexander and Utikal, Jochen (2014). RAGE ligand S100A8/A9 as a novel prognostic biomarker for high-risk melanoma patients.. 50th Annual Meeting of the American-Society-of-Clinical-Oncology, Chicago Il, May 30-Jun 03, 2014.
Neri, Dario, Weide, Benjamin, Eigentler, Thomas K., Pflugfelder, Annette, Zelba, Henning, Pawelec, Graham P., Giovannoni, Leonardo, Ruffini, Pier Adelchi, Elia, Giuliano, Gutzmer, Ralf, Becker, Juergen C. and Garbe, Claus (2014). Intralesional treatment of stage III metastatic melanoma patients with L19-IL2: Clinical and systemic immunological responses.. 50th Annual Meeting of the American-Society-of-Clinical-Oncology, Chicago Il, May 30-Jun 03, 2014.
Pflugfelder, A., Weide, B., Held, L., Eigentler, T., Leiter, U., Andonov, E., Dirschka, T., Stockfleth, E., Nashan, D. and Garbe, C. (2011). Long-term Findings of 3-Months versus 6-Months Treatment with 3% Diclofenac in 2,5% Hyaluronic Acid in Patients suffering from slight to moderate Actinic Keratoses - a multi-centric Study of the Working Group dermatological Oncology.
Weide, B., Zelba, H., Derhovanessian, E., Pflugfelder, A., Eigentler, T. K., Pawelec, G., Hoerr, I, Rammensee, H. G. and Garbe, C. (2010). Intradermal intranodal vaccine with Protamin stabilizes mRNA coding for cancer associated antigen - immune response and clinical course in 14 patients with melanoma.
Weide, B., Derhovanessian, E., Pflugfelder, A., Eigentler, T. K., Radny, P., Zelba, H., Pfoehler, C., Pawelec, G. and Garbe, C. (2009). FV1 High response rate and prolonged survival after intratumor treatment with interleukin-2-Results of a phase-II-study on 51 patients with metastatic melanoma. ESMO Scientific and Educational Conference (ESEC), Budapest Hungary, Jun 02-05, 2005. OXFORD UNIV PRESS.
Journal Article
Duffy, David L., Jagirdar, Kasturee, Lee, Katie J., McWhirter, Seamus R., McMeniman, Erin K., De’Ambrosis, Brian, Pflugfelder, Annette, Rayner, Jenna E., Whiteman, David C., Brown, Matthew A., Martin, N.G., Smithers, B.M., Schaider, Helmut, Soyer, H. Peter and Sturm, Richard A. (2020). Genes determining nevus count and dermoscopic appearance in Australian melanoma cases and controls. Journal of Investigative Dermatology, 140 (2), 498-501.e17. doi: 10.1016/j.jid.2019.05.032
Daley, G. M., Duffy, D. L., Pflugfelder, A., Jagirdar, K., Lee, K. J., Yong, X. L., Eigentler, T. K., Weide, B., Smithers, B. M., Martin, N. G., Garbe, C., Soyer, H. P. and Sturm, R. A. (2017). GSTP1 does not modify MC1R effects on melanoma risk. Experimental Dermatology, 26 (8), 730-733. doi: 10.1111/exd.13114
Wagner, Nikolaus B., Weide, Benjamin, Reith, Maike, Tarnanidis, Kathrin, Kehrel, Coretta, Lichtenberger, Ramtin, Pflugfelder, Annette, Herpel, Esther, Eubel, Jana, Ikenberg, Kristian, Busch, Christian, Holland-Letz, Tim, Naeher, Helmut, Garbe, Claus, Umansky, Viktor, Enk, Alexander, Utikal, Jochen and Gebhardt, Christoffer (2015). Diminished levels of the soluble form of RAGE are related to poor survival in malignant melanoma. International Journal of Cancer, 137 (11), 2607-2617. doi: 10.1002/ijc.29619
Stark, Mitchell S., Klein, Kerenaftali, Weide, Benjamin, Haydu, Lauren E., Pflugfelder, Annette, Tang, Yue Hang, Palmer, Jane M., Whiteman, David C., Scolyer, Richard A., Mann, Graham J., Thompson, John F., Long, Georgina V., Barbour, Andrew P., Soyer, H. Peter, Garbe, Claus, Herington, Adrian, Pollock, Pamela M. and Hayward, Nicholas K. (2015). The Prognostic and Predictive Value of Melanoma-related MicroRNAs Using Tissue and Serum: A MicroRNA Expression Analysis. EBioMedicine, 2 (7), 671-680. doi: 10.1016/j.ebiom.2015.05.011
Pflugfelder, A., Andonov, E., Weide, B., Dirschka, T., Schempp, C., Stockfleth, E., Stratigos, A., Krueger-Krasagakis, S., Bauer, J., Garbe, C. and Eigentler, T. K. (2015). Lack of activity of betulin-based Oleogel-S10 in the treatment of actinic keratoses: a randomized, multicentre, placebo-controlled double-blind phase II trial. British Journal of Dermatology, 172 (4), 926-932. doi: 10.1111/bjd.13342
Ugurel, S., Loquai, C., Kaehler, K., Hassel, J., Berking, C., Zimmer, L., Haubitz, I., Satzger, I., Mueller-Brenne, T., Mikhaimer, N. C., Becker, J. C., Kilian, K. J., Schadendorf, D., Heinzerling, L., Kaatz, M., Utikal, J., Goeppner, D., Pfoehler, C., Pflugfelder, A., Moessner, R. and Gutzmer, R. (2015). A multicenter DeCOG study on predictors of vemurafenib therapy outcome in melanoma: pretreatment impacts survival. Annals of Oncology, 26 (3), 573-582. doi: 10.1093/annonc/mdu573
Zelba, Henning, Weide, Benjamin, Martens, Alexander, Derhovanessian, Evelyna, Bailur, Jithendra Kini, Kyzirakos, Christina, Pflugfelder, Annette, Eigentler, Thomas K., Di Giacomo, Anna Maria, Maio, Michele, Aarntzen, Erik H. J. G., de Vries, Jolanda, Sucker, Antje, Schadendorf, Dirk, Buettner, Petra, Garbe, Claus and Pawelec, Graham (2014). Circulating CD4+ T cells that produce IL4 or IL17 when stimulated by Melan-A but not by NY-ESO-1 have negative impacts on survival of patients with stage IV melanoma. Clinical Cancer Research, 20 (16), 4390-4399. doi: 10.1158/1078-0432.CCR-14-1015
Meckbach, Diana, Keim, Ulrike, Richter, Sabina, Leiter, Ulrike, Eigentler, Thomas K., Bauer, Juergen, Pflugfelder, Annette, Buettner, Petra, Garbe, Claus and Weide, Benjamin (2014). BRAF-V600 mutations have no prognostic impact in stage IV melanoma patients treated with monochemotherapy. PLoS ONE, 9 (2), e89218. doi: 10.1371/journal.pone.0089218
Meckbach, Diana, Bauer, Juergen, Pflugfelder, Annette, Meier, Friedegund, Busch, Christian, Eigentler, Thomas K., Capper, David, von Deimling, Andreas, Mittelbronn, Michel, Perner, Sven, Ikenberg, Kristian, Hantschke, Markus, Buettner, Petra, Garbe, Claus and Weide, Benjamin (2014). Survival according to BRAF-V600 tumor mutations - an analysis of 437 patients with primary melanoma. PLoS ONE, 9 (1), e86194. doi: 10.1371/journal.pone.0086194
Abusaif, Sail, Jradi, Zeinab, Held, Laura, Pflugfelder, Annette, Weide, Benjamin, Meier, Friedegund, Garbe, Claus and Eigentler, Thomas K. (2013). S100B and lactate dehydrogenase as response and progression markers during treatment with vemurafenib in patients with advanced melanoma. Melanoma Research, 23 (5), 396-401. doi: 10.1097/CMR.0b013e3283650741
Pflugfelder, Annette, Kochs, Corinna, Blum, Andreas, Capellaro, Marcus, Czeschik, Christina, Dettenborn, Therese, Dill, Dorothee, Dippel, Edgar, Eigentler, Thomas, Feyer, Petra, Follmann, Markus, Frerich, Bernhard, Ganten, Maria-Katharina, Gaertner, Jan, Gutzmer, Ralf, Hassel, Jessica, Hauschild, Axel, Hohenberger, Peter, Huebner, Jutta, Kaatz, Martin, Kleeberg, Ulrich R., Koelbl, Oliver, Kortmann, Rolf-Dieter, Krause-Bergmann, Albrecht, Kurschat, Peter, Leiter, Ulrike, Link, Hartmut, Loquai, Carmen, Loeser, Christoph ... Schadendorf, Dirk (2013). Malignant Melanoma S3-Guideline "Diagnosis, Therapy and Follow-up of Melanoma". Journal der Deutschen Dermatologischen Gesellschaft, 11, 1-116. doi: 10.1111/ddg.12113_suppl
Weide, Benjamin, Faller, Christine, Elsaesser, Margrit, Buettner, Petra, Pflugfelder, Annette, Leiter, Ulrike, Eigentler, Thomas Kurt, Bauer, Juergen, Meier, Friedegund and Garbe, Claus (2013). Melanoma patients with unknown primary site or nodal recurrence after initial diagnosis have a favourable survival compared to those with synchronous lymph node metastasis and primary tumour. PLoS ONE, 8 (6), e66953. doi: 10.1371/journal.pone.0066953
Pflugfelder, Annette, Kochs, Corinna, Blum, Andreas, Capellaro, Marcus, Czeschik, Christina, Dettenborn, Therese, Dill, Dorothee, Dippel, Edgar, Eigentler, Thomas, Feyer, Petra, Follmann, Markus, Frerich, Bernhard, Ganten, Maria-Katharina, Gaertner, Jan, Gutzmer, Ralf, Hassel, Jessica, Hauschild, Axel, Hohenberger, Peter, Huebner, Jutta, Kaatz, Martin, Kleeberg, Ulrich R., Koelbl, Oliver, Kortmann, Rolf-Dieter, Krause-Bergmann, Albrecht, Kurschat, Peter, Leiter, Ulrike, Link, Hartmut, Loquai, Carmen, Loeser, Christoph ... Schadendorf, Dirk (2013). S3-Guideline "diagnosis, therapy and follow-up of melanoma" - short version. JDDG, 11 (6), 593-602. doi: 10.1111/ddg.12044
Forschner, Andrea, Heinrich, Vanessa, Pflugfelder, Annette, Meier, Friedegund and Garbe, Claus (2013). The role of radiotherapy in the overall treatment of melanoma. Clinics in Dermatology, 31 (3), 282-289. doi: 10.1016/j.clindermatol.2012.08.009
Weide, Benjamin, Faller, Christine, Buettner, Petra, Pflugfelder, Annette, Leiter, Ulrike, Eigentler, Thomas Kurt, Bauer, Juergen, Forschner, Andrea, Meier, Friedegund and Garbe, Claus (2013). Prognostic factors of melanoma patients with satellite or in-transit metastasis at the time of stage III diagnosis. PLoS ONE, 8 (4), e63137. doi: 10.1371/journal.pone.0063137
Weide, B., Elsaesser, M., Buettner, P., Pflugfelder, A., Leiter, U., Eigentler, T. K., Bauer, J., Witte, M., Meier, F. and Garbe, C. (2012). Serum markers lactate dehydrogenase and S100B predict independently disease outcome in melanoma patients with distant metastasis. British Journal of Cancer, 107 (3), 422-428. doi: 10.1038/bjc.2012.306
Weide, Benjamin, Zelba, Henning, Derhovanessian, Evelyna, Pflugfelder, Annette, Eigentler, Thomas K., Di Giacomo, Anna Maria, Maio, Michele, Aarntzen, Erik H. J. G., de Vries, I. Jolanda M., Sucker, Antje, Schadendorf, Dirk, Buettner, Petra, Garbe, Claus and Pawelec, Graham (2012). Functional T cells targeting NY-ESO-1 or Melan-A are predictive for survival of patients with distant melanoma metastasis. Journal of Clinical Oncology, 30 (15), 1835-1841. doi: 10.1200/JCO.2011.40.2271
Pflugfelder, A., Welter, A. -K., Leiter, U., Weide, B., Held, L., Eigentler, T. K., Dirschka, T., Stockfleth, E., Nashan, D. and Garbe, C. (2012). Open label randomized study comparing 3 months vs. 6 months treatment of actinic keratoses with 3% diclofenac in 2.5% hyaluronic acid gel: a trial of the German Dermatologic Cooperative Oncology Group. Journal of the European Academy of Dermatology and Venereology, 26 (1), 48-53. doi: 10.1111/j.1468-3083.2011.04005.x
Eigentler, Thomas K., Weide, Benjamin, de Braud, Filippo, Spitaleri, Gianluca, Romanini, Antonella, Pflugfelder, Annette, Gonzalez-Iglesias, Reinerio, Tasciotti, Annaelisa, Giovannoni, Leonardo, Schwager, Kathrin, Lovato, Valeria, Kaspar, Manuela, Trachsel, Eveline, Menssen, Hans D., Neri, Dario and Garbe, Claus (2011). A dose-escalation and signal-generating study of the immunocytokine L19-IL2 in combination with dacarbazine for the therapy of patients with metastatic melanoma. Clinical Cancer Research, 17 (24), 7732-7742. doi: 10.1158/1078-0432.CCR-11-1203
Weide, Benjamin, Eigentler, Thomas Kurt, Pflugfelder, Annette, Leiter, Ulrike, Meier, Friedegund, Bauer, Juergen, Schmidt, Diethard, Radny, Peter, Pfoehler, Claudia and Garbe, Claus (2011). Survival after intratumoral interleukin-2 treatment of 72 melanoma patients and response upon the first chemotherapy during follow-up. Cancer Immunology, Immunotherapy, 60 (4), 487-493. doi: 10.1007/s00262-010-0957-3
Pflugfelder, Annette, Eigentler, Thomas K., Keim, Ulrike, Weide, Benjamin, Leiter, Ulrike, Ikenberg, Kristian, Berneburg, Mark and Garbe, Claus (2011). Effectiveness of carboplatin and paclitaxel as first- and second-line treatment in 61 patients with metastatic melanoma. PLoS ONE, 6 (2), e16882. doi: 10.1371/journal.pone.0016882
Ikenberg, Kristian, Pflugfelder, Annette, Metzler, Gisela and Biedermann, Tilo (2011). Thirty-year history of Palmar eruptions: a quiz. Acta Dermato-Venereologica, 91 (1), 108-109. doi: 10.2340/00015555-0907
Pflugfelder, Annette, Weide, Benjamin, Eigentler, Thomas Kurt, Forschner, Andrea, Leiter, Ulrike, Held, Laura, Meier, Friedegund and Garbe, Claus (2010). Incisional biopsy and melanoma prognosis: facts and controversies. Clinics in Dermatology, 28 (3), 316-318. doi: 10.1016/j.clindermatol.2009.06.013
Leiter, Ulrike, Eigentler, Thomas Kurt, Forschner, Andrea, Pflugfelder, Annette, Weide, Benjamin, Held, Laura, Meier, Friedegund and Garbe, Claus (2010). Excision guidelines and follow-up strategies in cutaneous melanoma: Facts and controversies. Clinics in Dermatology, 28 (3), 311-315. doi: 10.1016/j.clindermatol.2009.10.001
Forschner, Andrea, Eigentler, Thomas Kurt, Pflugfelder, Annette, Leiter, Ulrike, Weide, Benjamin, Held, Laura, Meier, Friedegund and Garbe, Claus (2010). Melanoma staging: facts and controversies. Clinics in Dermatology, 28 (3), 275-280. doi: 10.1016/j.clindermatol.2009.06.012
Dirschka, T., Bierhoff, E., Pflugfelder, A. and Garbe, C. (2010). Topical 3.0% diclofenac in 2.5% hyaluronic acid gel induces regression of cancerous transformation in actinic keratoses. Journal of the European Academy of Dermatology and Venereology, 24 (3), 258-263. doi: 10.1111/j.1468-3083.2009.03399.x
Leiter, U., Forschner, A., Eigentler, T., Weide, B., Pflugfelder, A., Andonov, E., Held, L., Bauer, J., Meier, F. and Garbe, C. (2010). Follow-up examinations for melanoma: New aspects. Onkologe, 16 (12), 1175-1181. doi: 10.1007/s00761-010-1930-7
Weide, Benjamin, Pascolo, Steve, Scheel, Birgit, Derhovanessian, Evelyna, Pflugfelder, Annette, Eigentler, Thomay K., Pawelec, Graham, Hoerr, Ingmar, Rammensee, Hans-Georg and Garbe, Claus (2009). Direct Injection of Protamine-protected mRNA: Results of a Phase 1/2 Vaccination Trial in Metastatic Melanoma Patients. Journal of Immunotherapy, 32 (5), 498-507.
Garbe, Claus, Weide, Benjamin, Pflugfelder, Annette and Eigentler, Thomas (2009). Cutaneous Metastases of Melanoma: New Treatment Options. From Local Invasion to Metastatic Cancer: Involvement of Distant Sites Through the Lymphovascular System, 591-598. doi: 10.1007/978-1-60327-087-8_49